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Prevents Muscle Atrophy

The acceleration of nerve regeneration remains a clinical challenge.

Scores for the sciatic function index and pinprick test were significantly higher in the CO2 group than control group.

The muscle wet weight ratios of the tibialis anterior and soleus muscles were higher in the CO2 group than control group.

Electrophysiological examination showed that the CO2 group had higher compound motor action potential amplitudes and shorter distal motor latency than the control group.

Histological examination of the soleus muscle sections at postoperative week 2 showed shorter fiber diameter in the control group than in the CO2 group

The mRNA expression of Atrogin-1 and MuRF-1 was lower, mRNA expression of VEGF and myogenin and MyoD was higher in CO2 group at postoperative week 2 compared to the control group.

CLINICAL SIGNIFICANCE: Transcutaneous CO2 application has the therapeutic potential to accelerate the recovery of muscle atrophy in peripheral nerve injury.